The article considers modeling of nonlinear electrical conductivity of a biological cell using the equivalent circuit method. The paper proposes a nonlinear model of the electrical conductivity of a biological cell based on the use of nonlinear active and passive elements. The main mechanisms that determine the nonlinear nature of the electrical characteristics of a cell, including the phenomena of cell membrane polarization, are considered. To verify the model, a comparison of calculated and experimental data on the electrical parameters of biological cells is carried out. It is shown that the use of a nonlinear equivalent circuit allows more accurately reproducing the real behavior of cells in a wide range of applied voltages. The presented modeling technique can be applied to study the electrical properties of various types of biological cells, as well as to develop new electronic devices interacting with living systems. The article considers a complex nonlinear dependence of the electrical conductivity of a biological cell on voltage, which is caused by the interaction of two ion channels with different characteristics and resonance effects created by a series circuit. The method of equivalent circuits made it possible to create a single model that combines components responsible for ionic conductivity, capacitive properties of the membrane and resonance phenomena associated with the presence of electropores.

Keywords: mathematical modeling, equivalent circuit method, software, biological cell, computational research, electrical conductivity

The work is devoted to the study of the effect of electrical pulses on the processes of cisplatin transport through the plasma membrane. Technical devices based on the application of this technology are used to increase cellular uptake of cytotoxic agents within certain cancer treatment strategies. This article presents the results of mathematical modeling performed using computer methods that allow us to study the influence of different pulse parameters (amplitude, duration, frequency) on the efficiency of cisplatin transport. Numerical experiments using various difference schemes and mathematical models that take into account the physical properties of the plasma membrane have been performed. The results obtained allow us to better understand the mechanisms of the impact of electrical impulses on the processes of cisplatin transport, which may be of practical importance for the development of new methods of drug delivery and cancer treatment.

Keywords: mathematical modeling, software package, electroporation, cisplastin transport, plasma membrane, computational experiment